Q Chen*,
PC Cai*, THW Chang, E Burgener, MJ Kratochvil, A Gupta, A Hargill, PR Secor, JE Nielsen, AE Barron, SC Heilshorn, AJ Spakowitz, PL Bollyky (2024).
Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding.
Science Advances, 10(22), eadl5576.
This paper describes how electrostatic interactions and liquid crystalline structures synergistically promote Pseudomonas aeruginosa antibiotic tolerance with the presence of filamentous bacteriophages.
PC Cai*, M Braunreuther*, A Shih, AJ Spakowitz, SC Heilshorn, GG Fuller (2024).
Air-liquid intestinal cell culture allows in situ rheological characterization of intestinal mucus.
APL Bioengineering, 8(2), 11338.
This paper describes the development of an in vitro model of the intestinal mucus layer and a magnetic rheometer that probes the rheological changes in the mucus layer during intestinal worm infections.
PC Cai, B Su, L Zou, MJ Webber, SC Heilshorn, AJ Spakowitz (2022).
Rheological Characterization and Theoretical Modeling Establish Molecular Design Rules for Tailored Dynamically Associating Polymers.
ACS Central Science, 8(9), 1318-1327. [
code]
This paper experimentally validates the brachiation model using a biopolymer-based dynamic polymer system.
Q Chen, T Dharmaraj,
PC Cai, EB Burgener, NL Haddock, AJ Spakowitz, PL Bollyky (2022).
Bacteriophage Impact on Bacterial Susceptibility, Resistance, and Tolerance to Antibiotics.
Pharmaceutics, 14(7), 1425.
This review paper describes the role of bacteriophage in antibiotic resistance and tolerance.
MJ Kratochvil*, G Kaber*, S Demirdjian*,
PC Cai, EB Burgener, N Nagy, GL Barlow, MC Popescu, MR Nicolls, MG Ozawa, DP Regula, AE Pacheco-Navarro, S Yang, V de Jesus Perez, H Karmouty-Quintana, A Peters, B Zhao, LM Buja, PY Johnson, RB Vernon, TN Wight, Stanford COVID-19 Biobank Study Group, AJ Rogers, AJ Spakowitz, CE Milla, SC Heilshorn, PL Bollyky (2022).
Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections.
JCI Insight, 7(12).
This paper is about respiratory secretions in severe SARS-CoV-2 infections from a biochemical, biophysical, and immunological standpoint.
DR Hunt, KC Klett, S Mascharak, H Wang, D Gong, J Lou, X Li,
PC Cai, RA Suhar, JY Co, BL LeSavage, AA Foster, Y Guan, MR Amieva, G Peltz, Y Xia, CJ Kuo, SC Heilshorn (2021).
Engineered Matrices Enable the Culture of Human Patient-Derived Intestinal Organoids.
Advanced Science, 8(10).
This paper describes the development of intestinal organoids in an engineered extracellular matrix material.
BA Krajina, BL LeSavage, JG Roth, AW Zhu,
PC Cai, AJ Spakowitz, SC Heilshorn (2021).
Microrheology reveals simultaneous cell-mediated matrix stiffening and fluidization that underlie breast cancer invasion.
Science Advances, 7(8).
This paper describes using dynamic light scattering microrheology to study forces exerted by breast cancer spheroids on their extracellular matrix.
PC Cai, BA Krajina, MJ Kratochvil, L Zou, A Zhu, EB Burgener, PL Bollyky, CE Milla, MJ Webber, AJ Spakowitz, SC Heilshorn (2020).
Dynamic light scattering microrheology for soft and living materials.
Soft Matter, 17, 1929-1939. [
code]
This paper describes the set up and troubleshooting techniques for dynamic light scattering microrheology. Along with this paper, I also published a Python package that can be installed directly to contain all the relevant functions for analyzing the DLS instrument’s output. Documentation for this Python package as well as installation instructions can be found here.
PC Cai, BA Krajina, AJ Spakowitz (2020).
Brachiation of a polymer chain in the presence of a dynamic network.
Physical Review E, 102(020501(R)). [
PDF,
code]
This paper is about the theoretical development of the brachiation model for dynamic polymer networks.
